Frescolat MGA

Non Antibodies

TRPM8 channel

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

228, 33

An Activator of TRPM8 Channels

Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

41116134

Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 µM1.

Yes

Frescolat MGA is a synthetic compound that acts as a TRPM8 channel activator. Studies show that Frescolat MGA has the ability to activate mouse TRPM8 channels and to produce concentration-dependent increase in Ca2+ levels with an EC50 value of 4.8 µM1.TRPM8 channel is a member of the TRP channels superfamily. TRPM8 is Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8-28°C and by chemical agonists such as menthol and icilin. TRPM8 is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons and is up-regulated in prostate cancer and other malignancies1, 2.