GW 791343 hydrochloride

Non Antibodies

P2X7 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

483, 81

A Negative Allosteric Modulator of Human P2X7 Receptors

Soluble up to 100 mM in DMSO and in water. Centrifuge all products before handling (10000 x g 5 min).

41116134

GW 791343 hydrochloride is a species-specific allosteric modulator of the purinergic P2X7 receptors, acting as a negative modulator of human P2X7 (pIC50 = 6.9 - 7.2), and as a positive modulator of rat P2X71, 2.

Yes

GW 791343 hydrochloride is a species-specific allosteric modulator of purinergic P2X7 receptor. The compound acts as a negative modulator of human P2X7 receptors and as a positive modulator of rat P2X71. GW 791343 displays pIC50 values between 6.9 - 7.2 on human P2X7 receptors1, 2.P2X receptors are a family of ligand-gated cation channels activated by extracellular ATP, a ligand that mediates numerous cellular and biological functions. Seven members of P2X receptors are identified and shown to function either in homomeric or heteromeric combinations. The P2X receptors are widely localized in cell types of almost every origin, including neuronal, muscular, epithelial and immune and play a pivotal role in models of various pain conditions. P2X7 receptors are responsible for mediating the release of proinflammatory cytokines in inflammatory/immune conditions and pain1, 3, 4.