Ginkgolide B

S. Molecules

Israel

Storage as Solution: Up to four weeks at 4°C or three months at -20°C. - Storage after Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Lyophilized powder.

An Antagonist of 5-HT3A Channels

7, 4

Ginkgo biloba.

Ginkgolide B is a 5-HT3A channel blocker1.

Yes

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Ginkgolide B is a natural non-selective blocker of 5-HT3A channel. Ginkgolide is extracted from the leaves, roots and bark of the tree Ginkgo biloba. Ginkgolide B has an effective concentration of 500-1000 μM and an IC50 of 730 μM for the 5-HT3A receptor and an IC50 of 3.9 mM for the 5-HT3B receptor thus enabling discrimination between the two. Ginkgolide also binds to anion Cys-loop receptors such as GABA and glycine receptors. Ginkgolide does not displace the specific 5-HT3 receptor antagonist granisetron, thus confirming that it does not act at the agonist binding site. In addition, inhibition by Ginkgolide at 5-HT3A receptors is weakly use-dependent, and recovery of the receptor is also activity dependent, indicating channel block as the mechanism of inhibition. Ginkgolide is widely used in traditional medicine and has a wide spectrum of beneficial properties such as anti-convulsion, neuro-protection and reducing anxiety2.