Gambogic amide

Non Antibodies

TrkA receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

627, 78

A Selective Agonist of TrkA Receptors

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

41116134

Gambogic amide, an NGF-mimetic small molecule, is a TrkA receptor agonist, shown to selectively bind, activate and upregulate the expression of TrkA receptors at nanomolar concentrations (Kd = 75 nM). Gambogic amide shows antiapoptotic activity (EC50 = 5 nM), neuroprotective and anti-cancer effects in vitro and in vivo1-3.

Yes

Gambogic amide, is a small molecule that mimics nerve growth factor (NGF) and is a selective agonist of TrkA receptor that strongly induces its tyrosine phosphorylation and downstream signaling activation.Gambogic amide interacts with the cytoplasmic juxtamembrane domain of TrkA receptor and triggers its dimerization. It selectively binds, activates and upregulates the expression of TrkA receptors at nanomolar concentrations but not TrkB or TrkC.Gambogic acid is a major active ingredient of gamboge, a resin exuded from the Garcinia hanburyi tree in southeast Asia. Gambogic amide also possesses neurotrophic activity in various neural injury animal models and prevents glutamate-induced neuronal cell death1, 2.Gambogic amide shows antiapoptotic activity and demonstrates EC50 value of 5 nM3.