LY278584

S. Molecules

Israel

Storage as Solution: Up to four weeks at 4°C or three months at -20°C. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Lyophilized powder.

A Potent Antagonist of 5-HT3 Receptors

7, 4

3970

LY278584 is a specifiic 5-HT3 antagonist. 0.1 μM completely blocks 1 μM 5HT evoked current in Xenopus oocytes1.

Yes

LY278584 is a potent and selective antagonist of 5-HT3 receptors. Its structure is very similar to granisetron, also a 5-HT3 receptor antagonist. LY278584 is a useful ligand for studying the localization of 5-HT3 receptors in rat brain1, 2.Numerous studies have shown that 5-HT3 antagonism is able to modulate mesolimbic dopaminergic activity in rodents. There is evidence that blockade of 5-HT3 receptors may be involved in nociception. Another study conducted on 5-HT3 antagonism showed that LY278584 significantly inhibits high frequency electroacupuncture antinociception in early stages3.The 5-HT3 receptors mediate the action of serotonin in the body. These receptors are members of the Cys-loop ligand-gated cation channels, which are expressed throughout the central and peripheral nervous systems and mediate a variety of physiological functions such as emotion, cognition, memory, pain perception, and gastrointestinal functions including secretion and motility4.