ML-301

Item no.	ALO-M-315-25mg
Manufacturer	Alomone
CASRN	1531633-84-7
Amount	25 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Glucose Homeostasis Reagents & Chemicals Molecules
Type	Small Molecules
Format	Lyophilized
Specific against	other
Purity	>98%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Non Antibodies
Manufacturer - Category	S. Molecules
Manufacturer - Targets	Neurotensin Receptor 1
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage as Solution: Store at -20°C.It is recommended to aliquot stock solutions to prevent repeated thawing and freezing. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	522, 99
Manufacturer - Format	Lyophilized Powder
Short description	A Selective Agonist of Neurotensin Receptor 1
Description	ML301 - A Selective Agonist of Neurotensin Receptor 1
Reconstitution	Soluble in DMSO.Centrifuge all products before handling (10000 x g 5 min).
PH	7, 4
UNSPSC	41116134
Effective Concentration	1 nM - 1 µM.
Activity	ML-301 is a selective agonist of NTR1 receptors, shown to stimulate NTR1-mediated calcium mobilization with EC50 of 289 nM1-2.
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Bioassay tested	Yes
Chemical Name	(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2, 6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid.
Scientific Background	ML-301 is a fully selective imidazole-based agonist of neurotensin receptor 1 (NTR1). It stimulates NTR1-mediated calcium mobilization with an EC50 value of 289 nM1. The carboxylic acid moiety increases the compound's solubility1.To date, four neurotensin receptors have been cloned from human: NTR1, NTR2, NTR3 and NTR4 which belong to the super family of G-protein coupled receptors (GPCRs). NTR1 mediates most of the known neurotensin ligand effects and is a potential therapeutic target2.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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ALO-M-315-25mg-safety-datasheet.pdf