PD 123319 ditrifluoroacetate

Non Antibodies

AT2R receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

736, 66

A Potent and Selective Antagonist of Angiotensin II Receptor Type-2

Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

41116134

An Angiotensin II Type 2 Receptor Antagonist1, 2.

Yes

PD 123319 ditrifluoroacetate is a potent and selective antagonist of Angiotensin II type 2 receptor (AT2R) with an IC50 value of 34 nM3. It is also a weak Angiotensin II type 1 receptor antagonist. PD 123319 blocks the activation of the receptor by angiotensin II (Ang II), a natural hormone produced in order to maintain normal regulation of the cardiovascular function1.Blocking the angiotensin system has an important role in preventing progressive renal dysfunction and cardiovascular morbidity and mortality by reducing blood pressure and proteinuria. Ang II receptor antagonists are useful tools for treatment of chronic kidney disease in diabetic and non-diabetic patients2.