SDZ 205-557 hydrochloride

Non Antibodies

5-HT3, 5HT4 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

337, 2

An Antagonist of 5-HT3 Channels and 5-HT4 Receptors

Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

41116134

SDZ 205-557 hydrochloride is a 5-HT3 and 5-HT4 receptor antagonist1.

Yes

SDZ 205-557 is a potent 5-HT3 and 5-HT4 receptor antagonist with a greater affinity for 5-HT4 receptor with a Ki value of 10.6 nM3. It lacks affinity for other 5-HT receptors. SDZ 205-557 is thus suggested to be used as a useful ligand to characterize and define the 5HT-4 receptor. SDZ 205-557 has the ability to cross the blood brain barrier and has a short duration of action that may complicate its use in vivo1, 3.5-HT3 and 5HT4 are members of the serotonin-gated and G protein coupled receptor superfamily respectively. 5-HT3 receptors are expressed throughout the central and peripheral nervous systems. High levels of 5-HT4 receptors can be found in the olfactory system, striatum, hippocampus, and substantia nigra2, 3.