SR 48692

Non Antibodies

Neurotensin Receptor 1

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

587, 07

A Potent and Selective Antagonist of Neurotensin Receptor 1

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

41116134

SR 48692 is a potent and selective non-peptide antagonist of NTS1 receptors, shown to inhibit neurotensin-stimulated IP production (Ki = 2.45 nM) and NTR1-mediated calcium mobilization1-3.

Yes

SR 48692 is a potent and selective antagonist of neurotensin receptor 1 (NTR1/NTS1). The compound demonstrates hydrophobic and aromatic features1, 2. SR 48692 has been shown to antagonize neurotensin receptor actions in intestinal preparations, thus considered to be a useful tool in studying the physiological role of neurotensin receptor in the digestive tract. in vitro studies show that SR 48692 antagonizes NT-induced dopamine release in guinea pig striatal slices and NT-stimulated Ca2+ mobilization in HT29 cells1. In guinea pig ileum preparations, the compound displays an IC50 value of 33.5 nM1.The two neurotensin receptors, NTR1 and NTR2, belong to the family of G-protein-coupled receptors1, 2. The receptors are expressed in the brain and gastrointestinal tract where they play a role in pain transmission and intestinal motility.