Staurosporine

S. Molecules

Israel

Storage as Solution: Up to one week at 4°C or three months at -20°C.Protect from light.

Lyophilized powder.

Antibiotic AM-2282 - A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G

7, 4

Streptomyces staurosporeus.

Staurosporine potently inhibits a variety of kinases including PKC (IC50 = 0.7 nM), PKA (IC50 = 7 nM) and PKG (IC50 = 8.5 nM)1, 2. It also inhibits CaMK (IC50 = 20 nM)3 and MLCK (IC50 = 1.3 nM)1, 2. In addition, Staurosporine can act as an agonist promoting neurite outgrowth4. At higher concentrations, Staurosporine induces apoptosis5.

Yes

Staurosporine is a member of the K252a family of fungal alkaloids produce by Streptomyces staurospores.1, 2 It is one of the most potent, cell permeable protein kinase inhibitors, and it is often used to study the involvement of protein kinases in signal transduction pathways (IC50 0.7-20 nM).3-10In pheochromocytoma PC12 cells, neuroblastoma and brain primary culture Staurosporine is a functional neurotropins agonist promoting neurite outgrowth (EC50 = 50 nM).11-12 At concentrations higher then 0.5 mM, Staurosporine generates apoptosis in several different cell types or induces G1 and G2 phase arrest in normal cells.13-16