Comparison

Conantokin G European Partner

Item no. ALO-STC-666-1mg
Manufacturer Alomone
CASRN 93438-65-4
Amount 1 mg
Quantity options 0.5 mg 10 mg 1 mg 2.5 mg 5 mg
Category
Type Molecules
Format Lyophilized
Specific against other
Purity ≥98% (HPLC)
Formula Lyophilized from double distilled water (ddH2O).
Sequence GEXXLQXNQXLIRXKSN-NH<sub>2</sub>
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Shipping Condition Room temperature
Available
Manufacturer - Type
Non Antibodies
Manufacturer - Applications
Electrophysiology
Manufacturer - Category
Proteins
Manufacturer - Targets
GluN2B receptor
Country of Origin
Israel
Shipping Temperature
The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.
Storage Conditions
Storage as Solution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight
2264.2 Da
Manufacturer - Format
Lyophilized
Short description
A Selective and Competitive Antagonist of GluN2B Receptor
Description
Con-G, CGX-1007, Conotoxin GV, Sleeper peptide - A Selective and Competitive Antagonist of GluN2B Receptor
Reconstitution
Centrifuge the vial (10, 000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Specificity

A Selective and Competitive Antagonist of GluN2B Receptor

PH
7, 4
UNSPSC
12352202
Origin
Conus geographus (Geography cone) (Nubecula geographus)
Modifications

X = 4-Carboxyglutamate,

Asp17 - C-terminal amidation

Effective Concentration
500 nM
Activity
ConantokinG is a GluN2B competitive antagonist1.
Solubility
Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Sterile endotoxin free
no
Bioassay tested
yes
Scientific Background
Conantokin G is a 17 amino acid peptide toxin originally isolated from Conus geographus venoM The toxin acts as a selective antagonist of the GluN2B, a subunit of NMDA receptors1-3. Conantokin G structure includes γ-carboxiglutamic acid which coordinates binding of 4 calcium ions1, 2.Conantokin G has IC50 values of 0.48 µM in hippocampal and cortical neurons, and 0.1 µM in Xenopus oocytes expressing the GluN1-GluN2B subunits1. In vitro studies of neuronal cultures have revealed anti-apoptotic properties of Conantokin G. In animal models, Conantokin G has been successfully tested as an anti-convulsant and as an anti-analgesic agent.NMDA receptors belong to the family of ionotropic receptors coactivated by glutamate and glycine. They play a central role in neuronal plasticity, learning, and memory3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 mg
Available: In stock
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