Conantokin R

Non Antibodies

Proteins

Israel

Storage as Solution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Lyophilized

Con-R - An Antagonist of GluN2A and GluN2B Receptors

An Antagonist of GluN2A and GluN2B Receptors

12352202

Disulfide bonds between: Cys²¹-Cys²⁵ 

X = 4-Carboxyglutamate

Conantokin R is a potent and non-competitive NMDA receptor 2A/B antagonist1.

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Conantokin R is a peptide toxin originally isolated from the Conus radiatus (Rayed cone) venom, and preferentially antagonizes GluN2A and GluN2B NMDA receptors1, 2, 4. Conantokins are a group of short linear peptides (17-27 amino acids) originally isolated from the venom of cone snails. They structurally possess a high degree of alpha-helicity in the presence of divalent cations, and contain gamma-carboxyglutamic acid residues. Four naturally occurring conantokins have been identified and characterized to date, Conantokin G, Conantokin T, Conantokin R, and Conantokin-L1, 2.Conantokins appear to function by inhibiting the spermine/spermidine stimulation of ion flow through the NMDAR channel and different conantokin species present different NMDA receptor subunit specificity3.NMDR inhibition by conantokins is related to various human pathologies including pain, convulsive disorders, stroke, and Parkinson's disease. The potential pharmacological selectivity of conantokins, coupled to their efficacy in preclinical disease model and favorable safety profiles, indicate that these peptides represent both novel probes for NMDA receptor function as well as an important class of compounds for continued investigation as human therapeutics1.