Tropanyl-3,5-dimethylbenzoate

Non Antibodies

5-HT3 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

273, 4

An Antagonist of 5-HT3 Receptors

50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

Tropanyl-3, 5-dimethylbenzoate is a 5-HT3 receptor antagonist1.

Yes

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Tropanyl-3, 5-dimethylbenzoate is a synthetic, potent and selective antagonist of the 5-HT3 receptor. Tropanyl-3, 5-dimethylbenzoate has an effective concentration of 1 nM - 1 μM. Interestingly, in rat mucosa and submucosa preparations Tropanyl causes an increase of 5-HT induced Δ/sc (change in short circuit current) and causes a decline of Δ/sc in rat intact colon suggesting a double role for 5-HT3 receptors in this tissue2.