Comparison

Tetrodotoxin citrate European Partner

Item no. ALO-T-550-50ug
Manufacturer Alomone
CASRN 18660-81-6
Amount 50 ug
Quantity options 1 mg 50 ug 5 x 1 mg
Category
Type Small Molecules
Format Lyophilized
Specific against other
Purity >99% (HPLC)
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Shipping Condition Room temperature
Available
Manufacturer - Type
Non Antibodies
Manufacturer - Applications
Electrophysiology
Manufacturer - Category
S. Molecules
Manufacturer - Targets
Various NaV channels
Country of Origin
Israel
Shipping Temperature
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions
Storage as Solution: Up to one week at 4°C or six months at -20°C.
Molecular Weight
319, 27
Manufacturer - Format
Lyophilized
Short description
A Classic Blocker of a Subset of NaV Channels
Description
TTX - Tetrodotoxin citrate (#T-550) is a highly pure, natural, and biologically active compound.
Reconstitution
Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. TX citrate is freely soluble in water to over 10 mM The reconstituted product contains citrate buffer.To reconstitute 1 mg lyophilized product to 10 mM stock solution - add 313 µl ddH2O to the vial and tap gently until fully dissolved. To reconstitute 50 µg lyophilized product to 1 mM stock solution - add 157 µl ddH2O to the vial and tap gently until fully dissolved.Centrifuge all product vials before handling and reconstitution (10000 x g 5 min).
Specificity
A Classic Blocker of a Subset of NaV Channels
PH
7, 4
UNSPSC
41116134
Origin
Tetraodon pardalis (puffer fish).
Effective Concentration
100 nM - 1 μM
Activity
Tetrodotoxin is a potent and selective blocker of a subclass of NaV channels1, and is often used to define subclasses of NaV channels2.
Solubility
Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. TX citrate is freely soluble in water to over 10 mM The reconstituted product contains citrate buffer.
To reconstitute 1 mg lyophilized product to 10 mM stock solution - add 313 µl ddH2O to the vial and tap gently until fully dissolved. To reconstitute 50 µg lyophilized product to 1 mM stock solution - add 157 µl ddH2O to the vial and tap gently until fully dissolved.
Centrifuge all product vials before handling and reconstitution (10000 x g 5 min).
Bioassay tested
Yes
Chemical Name
Octahydro-12-(hydroxymethyl)-2-imino-5, 9:7, 10a-dimethan o-10aH-[1, 3]dioxocino[6, 5-d]pyrimidine-4, 7, 10, 11, 12-pentol.
Scientific Background
Tetrodotoxin (TTX) is an established potent and selective blocker of some NaV channels.1 Moreover, TTX sensitivity is used to define subclasses of NaV channels.2 It is widely used both to probe NaV activity and to reduce or block excitability in neurophysiological preparations.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ug
Available: In stock
available

Delivery expected until 12/4/2025 

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