Tyrphostin AG 490

Non Antibodies

JAK

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

294, 31

A JAK Inhibitor

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

Tyrphostin AG 490 is a potent inhibitor of JAK2 and JAK3. In addition, Tyrphostin AG 490 inhibits the JAK3/STAT, JAK3/AP-1, and JAK3/MAPK pathways and their cellular consequences1.

Yes

Tyrphostin AG-490 (AG-490) is synthetic tyrphostin derived from benzylidine malononitrile.1 At relatively low concentrations, AG-490 was found to be a highly efficient tyrosine kinase inhibitor for hyperactive forms of Jun kinase 2, 3 and 5 (Jak 2, 3, and 5).While many kinase inhibitors are often promiscuous in the enzymes they target, AG-490 is unique in that it does not inhibit other lymphocytic tyrosine kinases such as Lck, Lyn, Btk, Syk, Src, Jak1, Zap70 or Tyk2. 2-6 AG-490 has also been shown to inhibit cytokine-induced activation of JAK2 in eosinophils stimulated with granulocyte-macrophage and in vascular smooth muscle cells and cardiac myocytes activated by angiotensin II. 7-9Some studies have demonstrated that AG-490 efficiently blocks STAT3 activation in mycosis fungoides-derived T cell lymphoma cells and induces apoptosis in myeloma cells.10-11