Triacsin C

Non Antibodies

Israel

Storage as Solution: Up to two weeks at 4°C or six months at -20°C.Protect from light.

Lyophilized Powder

An Acyl CoA Synthase Inhibitor

7, 4

Streptomyces aureofaciens.

Triacsin C nearly completely inhibits de novo synthesis of triacylglycerol and phospholipids1, 2.

Yes

Triacsin C is a fungal metabolite from Streptomyces aureofaciens1 which almost completely inhibits de novo synthesis of triacylglycerol and phospholipid.2, 3 This compound specifically inhibits the activity of long chain acyl-CoA synthetase 1 and 4 (IC50~8µM) but has no effect on the activity of acyl-CoA synthetase 5, in intact cells and in cell lysates. Inhibition of these enzymes causes a decrease in the cellular levels of acyl-CoA precursors for lipid synthesis activity, cell proliferation and lipid transformation.4 Kinetic analysis indicates that inhibition of acyl-CoA synthetase by Triacsin C is not competitive with respect to the two substrates of acyl-CoA synthetase (ATP and coenzyme A), but is competitive with respect to long-chain fatty acids. The N-hydroxytriazene moiety of Triacsin C has been suggested to be essential for the inhibitory activity against acyl-CoA synthetase.2-4Triacsin C arrests the metabolism of arachidonic acid by inhibition of arachidonoyl-CoA synthetase thus interfering in the production of prostaglandins and in the regulation of blood pressure.5