Tyrphostin AG 1296

Non Antibodies

PDGF Receptor Tyrosine Kinase

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

266, 3

A PDGF Receptor Tyrosine Kinase Inhibitor

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

Tyrphostin AG 1296 is a highly selective blocker of platelet-derived growth factor (PDGF) α and β receptor tyrosine kinase1-3. It could also inhibit the signalling of stem cell factor (SCF) receptor (c-kit) and FLT3-ITD receptor4, 5.

Yes

Tyrphostin AG1296 is a tyrosine kinase blocker which selectively inhibits platelet-derived growth factor (PDGF) a- and b-receptor kinases and the PDGF-dependent signaling in many cell types. Tyrphostin AG1296 also inhibits the PDGF dependent transactivation of the P2Y and Endothelin receptors-evoked cell proliferation and MAPK activation.1-4This PDGF receptor (PDGFR) blocker has no effect on epidermal growth factor (EGF) receptor autophosphorylation; weak effects on DNA synthesis stimulated by insulin, by EGF, or by a combination of both; and over an order of magnitude weaker blocking effect on fibroblast growth factor-dependent (FGF) DNA synthesis.5-8 Tyrphostin AG1296 also potently inhibits the signaling of stem cell factor (SCF) receptor (c-Kit) and its upstream effector Kit receptor tyrosine kinase and the tyrosine kinase activity of FLT3-ITD which both have a strong sequence similarity with other members of the class III receptor tyrosine kinase but has no effect on the autophosphorylation of vascular endothelial growth factor (VEGF) receptor. 7, 8