IBR2

Manufacturer	ChemScene
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Amount	5mg
Item no.	CS-0034478-5mg
eClass 6.1	32169090
eClass 9.0	32169090
Available
CAS	313526-24-8
Purity	>98%
Formula	C24H20N2O2S
MWt	400.49
Solubility	DMSO : >= 150 mg/mL (374.54 mM)
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage
Target	RAD51
Biological Activity	IBR2 is a specific RAD51 inhibitor. IC50 & Target: RAD51^[1] In Vitro: IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC₅₀ values of the original IBR2 are in the range of 12-20 uM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC₅₀ of 14.8 uM^[1].

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