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SBI-115

SBI-115

Item no.	CS-0043229-25mg
Manufacturer	ChemScene
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	882366-16-7
Available
CAS	882366-16-7
Purity	>98%
Formula	C14H13ClN2O4S
MWt	340.78
Solubility	DMSO : 150 mg/mL (440.17 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein
Target	GPCR19
Biological Activity	SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5^[1]. In Vitro: SBI-115 (100-200 uM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25mg

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