Minoxidil

38304-91-5

209.25

DMSO : 4.6 mg/mL (21.98 mM; Need ultrasonic and warming); Ethanol : 7.14 mg/mL (34.12 mM; Need ultrasonic); H2O : 1 mg/mL (4.78 mM; ultrasonic and warming and heat to 50C)

Membrane Transporter/Ion Channel

Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 uM^[1][2][3]. IC50 & Target: IC50: 20 uM (soybean lipoxygenaseare)^[1]; ATP-sensitive potassium channel^[2] In Vitro: Minoxidil (1-00 uM; 24 hours; RAMEC cells) treatment shows very low cytotoxicities in the whole area of concentrations examined (from 1 uM to 100 uM)^[1]. In Vivo: Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)^[1].