Doxycycline (hyclate)

24390-14-5

512.94

H2O : 13.89 mg/mL (27.08 mM; Need ultrasonic)

Metabolic Enzyme/Protease; Anti-infection; Anti-infection; Anti-infection

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor^[1]. In Vitro: Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) affects growth of glioma cells only under high concentrations^[2].
Doxycycline (hyclate) decreases MT-CO1 protein content with concentrations of 1 ug/mL and higher in SVG cells^[2].
Doxycycline (1 ug/mL) induce short-hairpin RNA (shRNA) expression in H23 cells^[3]. In Vivo: Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner^[1].