OAC1

Manufacturer	ChemScene
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Amount	50mg
Item no.	CS-4181-50mg
eClass 6.1	32169090
eClass 9.0	32169090
Available
CAS	300586-90-7
Purity	>98%
Formula	C14H11N3O
MWt	237.26
Solubility	DMSO : >= 40 mg/mL (168.59 mM)
Clinical Information	No Development Reported
Pathway	Stem Cell/Wnt
Target	Oct3/4
Biological Activity	OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process. IC50 value: Target: Oct4 activator in vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling.

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Delivery expected until 6/6/2024