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Sofiniclin

Sofiniclin

Manufacturer	ChemScene
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Amount	1mg
Item no.	CS-6792-1mg
eClass 6.1	32169090
eClass 9.0	32169090
Available
Alternative Names	ABT 894
CAS	799279-80-4
Purity	>98%
Formula	C10H11Cl2N3
MWt	244.12
Solubility	10 mM in DMSO
Clinical Information	Phase 2
Pathway	Neuronal Signaling; Membrane Transporter/Ion Channel
Target	nAChR; nAChR
Biological Activity	Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR), used as a potential non-stimulant treatment for attention-deficit/hyperactivity disorder (ADHD). In Vitro: Sofiniclin is more potent than ABT-089 at both receptor subtypes, with K_i values of 1.9 nM for ¹²⁵I-alpha-conotoxinMII binding and of 1.3 nM for ¹²⁵I-epibatidine binding^[1]. In Vivo: Sofiniclin (0.001 to 0.10 mg/kg, p.o.) produces significant reductions in LIDs compared to vehicle monkey^[1]. Sofiniclin (0.1 mg/kg) does not decrease LIDs in monkeys with severe nigrostriatal damage^[2].

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Delivery expected until 6/6/2024