KKL-10

Item no.	CS-6883-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	952849-76-2
Available
CAS	952849-76-2
Purity	>98%
Formula	C14H10BrN3O2S
MWt	364.22
Solubility	DMSO : 6.8 mg/mL (18.67 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Anti-infection
Target	Bacterial
Biological Activity	KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria. In Vitro: The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 ug/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 ug/mL. The combination of IFN-gamma stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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