Desaminotyrosine

501-97-3

C9H10O3

DMSO : >= 300 mg/mL (1805.27 mM)

Anti-infection; Metabolic Enzyme/Protease

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling. IC50 & Target: Type I interferon, Influenza virus^[1] In Vivo: Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice^[1].