E 2012

Item no.	TMO-T15184-50mg
Manufacturer	TargetMol
CASRN	870843-42-8
Amount	50 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.83%
Citations	Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K.Acute effect on the Abeta isoform pattern in CSF in response to gamma-secretase modulator and inhibitor treatment in dogs.J Alzheimers Dis. 2010;21(3):1005-12.
Smiles	COc1cc(\C=C2/CCCN([C@@H](C)c3ccc(F)cc3)C2=O)ccc1-n1cnc(C)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	870843-42-8,Gamma-secretase
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Gamma-secretase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	419.49
Description	E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.
Pathways	Stem Cells\|\|\|Proteases/Proteasome\|\|\|Neuroscience

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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