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Finerenone

Finerenone

Manufacturer	TargetMol
Category	Molecule
Type	Molecules
Specific against	other
Amount	50mg
Item no.	TMO-T21395-50mg
Approximate Leadtime	1-2 Weeks
eClass 6.1	32169090
eClass 9.0	32169090
Available
purity	99.65%
SMILES	O=C(C1=C(C)NC2=C(C(OCC)=NC=C2C)[CH]1C3=CC=C(C#N)C=C3OC)N
formula	C21H22N4O3
MolWt	378.43
Pathway	Endocrinology/Hormones
Target	Glucocorticoid Receptor
Bioactivity	Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold).
Reference	George L Bakris , Rajiv Agarwal , et al.Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.JAMA. 2015 Sep 1; 314(9):884-94.

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