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A-674563

A-674563

Item no.	V0164-5mg
Manufacturer	InvivoChem LLC
CASRN	552325-73-2
Amount	5 mg
Quantity options	100 mg 10 mg 1 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	552325-73-2
Available
Description	InvivoChem Cat #:V0164CAS #:552325-73-2Purity >=98% Description: A-674563 is a novel and potent Akt1 inhibitor with potential anticancer activity. It binds to Akt with a Ki of 11 nM in cell-free assays, and shows modest potency against PKA and > 30-fold selectivity for Akt1 over PKC. In MiaPaCa-2 cells treated with A-674563 for 48 hour, it slowed the tumor cell proliferation (EC50 = 0.4 um). In STS cells, phosphorylation of GSK3 and MDM2 was prominently reduced by A-674563 treatment. Akt inhibition-induced G2 cells cycle arrest and apoptosis were also observed in A563-treated STS cells. Description: Description: A-674563 is a novel and potent Akt1 inhibitor with potential anticancer activity. It binds to Akt with a Ki of 11 nM in cell-free assays, and shows modest potency against PKA and > 30-fold selectivity for Akt1 over PKC. In MiaPaCa-2 cells treated with A-674563 for 48 hour, it slowed the tumor cell proliferation (EC50 = 0.4 um). In STS cells, phosphorylation of GSK3 and MDM2 was prominently reduced by A-674563 treatment. Akt inhibition-induced G2 cells cycle arrest and apoptosis were also observed in A563-treated STS cells. References: Mol Cancer Ther. 2005 Jun; 4(6):977-86; Cancer Res. 2008 Apr 15; 68(8):2895-903. References:References:
Molecular Weight (MW)	358.44
Formula	C22H22N4O
CAS No.	552325-73-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 72 mg/mL (200.9 mM)
	Water: N/A
	Ethanol: 18 mg/mL (50.21 mM)
Solubility (In vivo)	Saline: 30 mg/mL
Other info	Synonym: A674563; A 674563; A-674563 Chemical Name: (S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine InChi Key: BPNUQXPIQBZCMR-IBGZPJMESA-N InChi Code: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8, 10-13, 19H, 9, 14, 23H2, 1H3, (H, 25, 26)/t19-/m0/s1 SMILES Code: N[CH](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(NN=C4C)C=C3)=CN=C2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 9/4/2025

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