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SNX-2112 (PF-04928473)

SNX-2112 (PF-04928473)

Item no.	V0888-5mg
Manufacturer	InvivoChem LLC
CASRN	908112-43-6
Amount	5 mg
Quantity options	100 mg 10 mg 1 mg 250 mg 25 mg 2 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	908112-43-6
Available
Description	InvivoChem Cat #:V0888CAS #:908112-43-6Purity >=98% Description: SNX-2112 (SNX2112; SNX 2112; PF-04928473; PF04928473) is a novel and potent HSP90 (Heat Shock Protein 90) with potential antitumor activity and was in phase 1 clinical trials. It selectively inhibits HSP90alpha and HSP90beta with Ka values of 30 nM and 30 nM. It exhibits excellent in vivoantitumor efficacy in in a xenograft murine model. Description:in a xenograft murine model. References: Clin Cancer Res. 2008 Jan 1; 14(1):240-8; Blood. 2009 Jan 22; 113(4):846-55. References:
Molecular Weight (MW)	464.48
Formula	C23H27F3N4O3
CAS No.	908112-43-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 93 mg/mL (200.2 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	0.5% CMC+0.25% Tween 80: 30mg/mL
Other info	Synonym: PF 04928473; SNX2112; SNX-2112; PF-04928473; PF04928473; SNX 2112; Chemical Name: 4-(6, 6-dimethyl-4-oxo-3-(trifluoromethyl)-4, 5, 6, 7-tetrahydro-1H-indazol-1-yl)-2-(((1r, 4r)-4-hydroxycyclohexyl)amino)benzamide InChi Key: ZFVRYNYOPQZKDG-MQMHXKEQSA-N InChi Code: InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24, 25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5, 8-9, 12, 14, 28, 31H, 3-4, 6-7, 10-11H2, 1-2H3, (H2, 27, 33)/t12-, 14- SMILES Code: O=C(N)C1=CC=C(N2N=C(C(F)(F)F)C3=C2CC(C)(C)CC3=O)C=C1N[CH]4CC[CH](O)CC4

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Amount: 5 mg

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