SNX-2112 (PF-04928473)

Description: SNX-2112 (SNX2112; SNX 2112; PF-04928473; PF04928473) is a novel and potent HSP90 (Heat Shock Protein 90) with potential antitumor activity and was in phase 1 clinical trials. It selectively inhibits HSP90alpha and HSP90beta with Ka values of 30 nM and 30 nM. It exhibits excellent in vivoantitumor efficacy in in a xenograft murine model.

References: Clin Cancer Res. 2008 Jan 1; 14(1):240-8; Blood. 2009 Jan 22; 113(4):846-55.

Synonym: PF 04928473; SNX2112; SNX-2112; PF-04928473; PF04928473; SNX 2112;

Chemical Name: 4-(6, 6-dimethyl-4-oxo-3-(trifluoromethyl)-4, 5, 6, 7-tetrahydro-1H-indazol-1-yl)-2-(((1r, 4r)-4-hydroxycyclohexyl)amino)benzamide

InChi Key: ZFVRYNYOPQZKDG-MQMHXKEQSA-N

InChi Code: InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24, 25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5, 8-9, 12, 14, 28, 31H, 3-4, 6-7, 10-11H2, 1-2H3, (H2, 27, 33)/t12-, 14-

SMILES Code: O=C(N)C1=CC=C(N2N=C(C(F)(F)F)C3=C2CC(C)(C)CC3=O)C=C1N[CH]4CC[CH](O)CC4