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Description: 4-Octyl Itaconate is a novel, potent and cell-permeable analog of itaconate, which is an emerging determinant of inflammation in activated macrophages and an anti-inflammatory metabolite that can activate Nrf2 (an anti-inflammatory transcription factorvia alkylation of KEAP1.
References: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5; 556(7699):113-117.
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