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Angiotensin II

Angiotensin II

Item no.	ALO-GPA-100-50mg
Manufacturer	Alomone
CASRN	4474-91-3
Amount	50 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Peptides & Proteins Western Blot Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Peptides By Organ Uterine, Ovarian & Cervical Cancer
Type	Peptides
Format	Lyophilized
Applications	WB
Specific against	other
Purity	≥98% (HPLC)
Formula	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Sequence	DRVYIHPF-OH
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Manufacturer - Type	Non Antibodies
Manufacturer - Category	Proteins
Manufacturer - Targets	Angiotensin II receptors
Country of Origin	Israel
Shipping Temperature	The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.
Storage Conditions	Storage as Solution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	1046.2 Da
Manufacturer - Format	Lyophilized
Short description	A Ligand of AT1 and AT2 G-Protein Coupled Receptors
Description	Ang II, Angiotensin-2 - A Ligand of AT1 and AT2 G-Protein Coupled Receptors
Reconstitution	Centrifuge the vial (10, 000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Specificity	A Ligand of AT₁ and AT₂ G-Protein Coupled Receptors
PH	7, 4
UNSPSC	12352202
Effective Concentration	1 - 300 nM
Activity	Angiotensin II regulates blood vessel tonus, blood pressure, and salt and water balance1-3.
Solubility	Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Sterile endotoxin free	no
Bioassay tested	yes
Scientific Background	Angiotensin II (Ang II) is a key factor in the Renin-Angiotensin-Aldosterone (RAAS) systeM Ang II is a derivative of a precursor molecule - angiotensinogen, a member of the serpin family. Angiotensinogen is a substrate of the Renin in the kidney to produce a deca peptide - Ang I, which appears to have no biological activity. Ang I is converted to Ang II by Angiotensin-Converting Enzyme (ACE)1, 2.The biological effects caused by Ang II are mediated by four Ang II receptor subtypes: AT1 and AT2. Ang II plays a critical role in the regulation of the renal and cardiovascular systems, and some activities in the central nervous systems. Circulating levels of Ang II were identified as controlling blood pressure, based on the regulation of salt and water metabolism, vascular smooth muscle cell tone, thirst, and sympathetic system outflow. Ang II is well known to cause potent increases in systemic and local blood pressure via its vasoconstrictive effect, to influence renal tubules, to retain Na+ and water by activating Na+/H+ exchangers, and by stimulating aldosterone release from the adrenal gland3.Ang II is also a cell growth modulator depending on the Ang II receptor subtype expressed in the cell membrane. It may either stimulate growth (proliferation, hypertrophy) or act as a growth suppressor3, 4.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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ALO-GPA-100-50mg-safety-datasheet.pdf