Comparison

human, rat Spexin-1 European Partner

Item no. ALO-SPS-100-2.5mg
Manufacturer Alomone
CASRN 1370290-58-6
Amount 2.5 mg
Quantity options 10 mg 1 mg 2.5 mg 5 mg
Category
Type Peptides
Format Lyophilized
Applications FA
Specific against other
Purity ≥98% (HPLC)
Formula Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Sequence NWTPQAMLYLKGAQ-NH<sub>2</sub>
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Shipping Condition Room temperature
Available
Manufacturer - Type
Non Antibodies
Manufacturer - Applications
Aequorin functional assay / Calcium imaging assay
Manufacturer - Category
Proteins
Manufacturer - Targets
Galanin 2, Galanin 3 receptors
Country of Origin
Israel
Shipping Temperature
The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.
Storage Conditions
Storage as Solution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight
1620 Da
Manufacturer - Format
Lyophilized
Short description
A Potent Agonist of Galanin 2 and Galanin 3 Receptors
Description
NPQ, Neuropeptide Q, Spexin hormone, NPQ 53-70 - A Potent Agonist of Galanin 2 and Galanin 3 Receptors
Reconstitution
Centrifuge the vial (10, 000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Specificity

A Potent Agonist of Galanin 2 and Galanin 3 Receptors

PH
7, 4
UNSPSC
12352202
Modifications
Gln14 - C-terminal amidation
Effective Concentration
20 - 50 nM
Activity
Spexin-1 is a Galanin 2 and Galanin 3 receptor agonist1.
Solubility
Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Sterile endotoxin free
no
Bioassay tested
yes
Scientific Background
Spexin-1 is a potent 14 amino acid neuropeptide that acts as a Galanin 2 (GALR2) and Galanin 3 (GALR3) receptor agonist, and shows no activity towards Galanin receptor 1.Expression of spexin-1 at the mRNA and protein levels are detected in the brain and in peripheral tissues of humans, mice and rats. Studies have shown that and administration of Spexin-1 leads to weight loss in rodents and suppresses appetite in goldfish1.GalR2 and GalR3 receptors are implicated in several biological functions, in which the central nervous system functions controlling memory, seizure, pain, anxiety, depression, and mood disorder2.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 2.5 mg
Available: In stock
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