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Human SIGLEC7 Protein, His Tag

Human SIGLEC7 Protein, His Tag

Item no.	DIM-PME100645-100ug
Manufacturer	DIMA Biotechnology
Amount	100 ug
Quantity options	100 ug 10 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
Host	HEK293
Conjugate/Tag	HIS
Purity	The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	AIRM-1,AIRM1,CD328,CDw328,D-siglec,p75,p75/AIRM1,QA79,SIGLEC-7,SIGLEC19P,SIGLECP2
Shipping condition	Room temperature
Available
Manufacturer - Category	ECD Proteins
Manufacturer - Targets	SIGLEC7
Manufacturer - Conjugate / Tag	C-6xHis Tag
Molecular Weight	The protein has a predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of SIGLEC7-His is approximately 55-70 kDa due to glycosylation.
Storage	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 3- and alpha-2, 6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34 cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).[UniProtKB/Swiss-Prot Function]
Molecular Characterization	SIGLEC7(Gln19-Leu353) 6xHis tag
Description	Recombinant human SIGLEC7 protein with C-terminal 6xHis tag
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Usage	Research use only

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/4/2025

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