Recombinant Mouse VEGF-A/VEGF164

Pichia Pastoris

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.

Recombinant Mouse Vascular Endothelial Growth Factor A is produced by our Yeast expression system & the target gene encoding Ala27-Arg190 is expressed.

Mouse Vascular endothelial growth factor (VEGF or VEGF­A), is a potent mediator of both angiogenesis & vasculogenesis in the fetus & adult. It is a member of the PDGF/VEGF growth factor family that is characterized by a cystine knot structure formed by eight conserved cysteine residues. Alternately spliced isoforms of 120, 164 & 188 aa found in mouse. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt­1) & VEGF R2 (Flk­/KDR) on endothelial cells.Although affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. VEGF is required during embryogenesis to regulate the proliferation, migration, & survival of endothelial cells.It may play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis.

Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Ala27-Arg190