Recombinant Mouse Lymphotoxin beta Receptor/LTBR/TNFRSF3/TNFRrp (C-Fc)

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.

Recombinant Mouse Lymphotoxin beta Receptor is produced by our Mammalian expression system & the target gene encoding Ser28-Pro218 is expressed with a Fc tag at the C-terminus.

It is a single-pass type I membrane protein & contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial & myeloid lineages, but not on T & B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA & LTB, & for TNFS14/LIGHT. It promotes apoptosis via TRAF3 & TRAF5 & may play a role in the development of lymphoid organs. The encoded protein & its ligand play a role in the development & organization of lymphoid tissue & transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity & leads to IL-8 release. TNFRSF3 is also essential for development & organization of the secondary lymphoid organs & chemokine release.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.