PKC412 (4'-N-Benzoyl Staurosporine, CGP 41251, Midostaurin)

Blue Ice

570, 64

Supplied as off-white to beige, tan or yellow solid.

The staurosporine analog, PKC412, inhibits a variety of serine/threonine and tyrosine kinases including PKC (IC50=50nM), cyclic AMP-dependent protein kinase (IC50=2.4uM), S6 kinase (IC50=5.0uM), and EGFR (epidermal growth factor receptor) tyrosine-kinase activity (IC50=3.0uM).

CAS Number:
120685-11-2

Molecular Formula:
C35H30N4O4

Molecular Weight:
570.64

Appearance:
Supplied as off-white to beige, tan or yellow solid..

Purity:
≥99%

Solubility:
Soluble in DMSO at 100mg/ml and in ethanol at 5mg/ml with warming. Very poorly soluble in water; maximum solubility in water is ~10-20uM; buffers, serum or other additives may increase or decrease aqueous solubility.

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.