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Human HER2 / ErbB2 Protein (Fc Tag)

Human HER2 / ErbB2 Protein (Fc Tag)

Manufacturer	Sino Biological
Category	Oncology Neuroscience Neural Adhesion Molecules By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer
Type	Proteins
Specific against	Human
Amount	2mg
Host	Human
Item no.	10004-H02H-2
eClass 6.1	34160400
eClass 9.0	42020190
Available
Molecule	ERBB2
Synonym	CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN19, NEU, NGL, TKR1
Storage	Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Protein Construction	A DNA sequence encoding the extracellular domain (Met 1-Thr 652) of human ErbB2 (NP_004439.2) was fused with the Fc region of human IgG1 at the C-terminus.
Expressed Host	Human Cells
Purity	> 90 % as determined by SDS-PAGE
Bio-Activity	Measured by its binding ability in a functional ELISA . Immobilized human ErbB2 at 2.5 ug/ml can bind Herceptin with a linear range of 3.2-80 ng/ml .
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method
Predicted N Terminal	Thr 23
Molecule Mass	The recombinant human ErbB2/Fc chimera is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The monomer comprises 868 amino acids and has a calculated molecular mass of 96.1 kDa. As a result of glycosylation, the monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4
Accession	NP_004439.2
Amino acid sequence	Met1-Thr652
TAG	C-human IgG1-Fc

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

10004-H02H-2-datasheet.pdf

10004-H02H-2-safety-datasheet.pdf