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Recombinant Human HMGB1 Protein (hFc Tag), HPLC-verified

Recombinant Human HMGB1 Protein (hFc Tag), HPLC-verified

Item no.	10326-H01H-2
Manufacturer	Sino Biological
Amount	2 mg
Quantity options	1 mg 2 mg 20 ug 4 mg 50 ug 500 ug
Category	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human (Homo sapiens)
Host	Human
Conjugate/Tag	Fc
Purity	> 97 % as determined by SDS-PAGE
Sequence	Met1-Glu215
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	HMG-1,HMG1,HMG3,SBP-1
Similar products	HMGB1
Available
Manufacturer - Type	Protein
Manufacturer - Conjugate / Tag	N-human IgG1-Fc
Shipping Temperature	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Storage Conditions	Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Antigen molecule name	HMGB1
Protein Construction	A DNA sequence encoding the human HMGB1 protein (NP_002119.1) (Met 1-Glu 215) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Expressed Host	Human Cells
Bio-Activity	Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse AGER at 2 ug/ml (100 ul/well) can bind human HMGB1. The EC50 of human HMGB1 is 0.23 ug/ml.
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method
Predicted N Terminal	Glu 20
Molecule Mass	The recombinant human HMGB1/Fc is a disulfide-linked homodimeric protein.The reduced monomer consists of 452 amino acids and has a predictedmolecular mass of 51.5 kDa. As a result of glycosylation, the apparent molecular mass of rhHMGB1/Fc monomer is approximately 55-60 kDa inSDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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