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Recombinant Human VEGFR3/FLT4 Protein (ECD, hFc Tag), HPLC-verified

Recombinant Human VEGFR3/FLT4 Protein (ECD, hFc Tag), HPLC-verified

Item no.	10806-H02H-1
Manufacturer	Sino Biological
Amount	1 mg
Quantity options	1 mg 100 ug 2 mg 4 mg
Category	Oncology By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Adenocarcinoma Mesothelioma By Organ Bladder Cancer
Type	Proteins
Specific against	Human (Homo sapiens)
Host	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	FLT-4, FLT-41, FLT41, LMPH1A, PCL, VEGFR-3, VEGFR3
Similar products	FLT4
Available
Manufacturer - Category	Protein
Molecule	FLT4
Synonym	FLT-4, FLT-41, FLT41, LMPH1A, PCL, VEGFR-3, VEGFR3
Storage	Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Protein Construction	A DNA sequence encoding the extracellular domain (Met 1-Ile 776) of human VEGFR3 (NP_002011.2) was expressed with the fused Fc region of human IgG1 at the C-terminus.
Expressed Host	Human Cells
Purity	> 97 % as determined by SDS-PAGE
Bio-Activity	Measured by its binding ability in a functional ELISA . 1. Immobilized recombinant human VEGFR3 at 5 ug/ml (100 ul/well) can bind recombinant human VEGF-D at a linear range of 62.5-2000 ng/ml. 2. Immobilized recombinant human VEGF-C at 10 ug/ml (100 ul/well) can bind recombinant human VEGFR3 at a linear range of 0.64-80 ng/ml. 3. Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM.
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method
Predicted N Terminal	Tyr 25 & Ser 473
Molecule Mass	The recombinant human VEGFR3/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 990 amino acids and predicts a molecular mass of 111 kDa. As a result of glycosylation and proteolytic cleavage, rhVEGFR3/Fc migrates as three bands (160, 85, 75 kDa) corresponding to the full length and the cleaved two polypeptides respectively in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4
Accession	NP_002011.2
Amino acid sequence	Met1-Ile776
TAG	C-human IgG1-Fc

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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