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Recombinant Horse Interleukin-1 Receptor Antagonist protein (IL1RN) (Active)

Recombinant Horse Interleukin-1 Receptor Antagonist protein (IL1RN) (Active)

Manufacturer	Biomatik
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Obesity
Type	Proteins Recombinant
Specific against	Equine
Amount	100ug
Item no.	BM-RPC26545-100ug
Targets	CD121a;;IL6R
eClass 6.1	34160400
eClass 9.0	42020190
Available
Gene Name	IL1RN
Alternative Names	Interleukin-1 receptor antagonist protein Short name: IL-1RN Short name: IL-1ra Short name: IRAP Alternative name(s): IL1 inhibitor
Uniprot	O18999
Source	E.coli
Expression Region	26-177aa
AA Sequence	HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VA GYLQESNT KLQEKIDVVP IEPDALFLGL HGRK LCLACV KSGDEIRFQL EAVNITDLSK NKEENK RFTF IRSNSGPTTS FESAACPGWF LCTAQEAD RP VSLTNKPKES FMVTKFYLQE DQ
Sequence Info	Full Length of Mature Protein
Tag Info	Tag-Free
Theoretical MW	17.4 kDa
Purity	>95% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.4
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by inhibiting IL-1alpha- dependent proliferation of murine D10S cells is less than 3.0 ug/ml, corresponding to a specific activity of ? 333 IU/mg in the presence of 50 pg/ml rHuIL-1alpha.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Function	Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Subcellular location	Secreted
Protein Families	IL-1 family

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 6/27/2024