Item no. |
DIM-PME100005-10ug |
Manufacturer |
DIMA Biotechnology
|
Amount |
10 ug |
Quantity options |
100 ug
10 ug
50 ug
|
Category |
|
Type |
Proteins |
Format |
Lyophilized |
Specific against |
Human (Homo sapiens) |
Host |
HEK293 |
Conjugate/Tag |
HIS, Fc |
Purity |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CD22, SIGLEC2, BL-CAM, SIGLEC-2, Siglec2, SIGLEC2FLJ22814 |
Similar products |
CD22, SIGLEC2, BL-CAM, SIGLEC-2, Siglec2, SIGLEC2FLJ22814 |
Shipping condition |
Room temperature |
Available |
|
Manufacturer - Category |
ECD Proteins |
Manufacturer - Targets |
CD22 |
Manufacturer - Conjugate / Tag |
C-Human Fc and 6xHis Tag |
Molecular Weight |
The protein has a predicted molecular mass of 102.1 kDa after removal of the signal peptide. The apparent molecular mass of CD22-hFc-His is approximately 130-180 kDa due to glycosylation. |
Storage |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background |
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
Molecular Characterization |
CD22(Asp20-Arg687) hFc(Glu99-Ala330) 6xHis tag |
Description |
Recombinant human CD22 protein with C-terminal human Fc and 6xHis tag |
Formulation & Reconstitution |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Usage |
Research use only |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.