Item no. |
DIM-PME100023-50ug |
Manufacturer |
DIMA Biotechnology
|
Amount |
50 ug |
Quantity options |
100 ug
10 ug
50 ug
|
Category |
|
Type |
Proteins |
Format |
Lyophilized |
Applications |
WB, ELISA |
Specific against |
other |
Host |
HEK293 |
Conjugate/Tag |
HIS, Fc |
Purity |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1 |
Shipping condition |
Room temperature |
Available |
|
Manufacturer - Type |
Recombinant |
Manufacturer - Category |
ECD Proteins |
Manufacturer - Targets |
PDL1 |
Manufacturer - Conjugate / Tag |
C-Mouse Fc and 6xHis Tag |
Molecular Weight |
The protein has a predicted molecular mass of 52.3 kDa after removal of the signal peptide. |
Buffer |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 30 % trehalose is added as protectants before lyophilization. |
Purification |
affinity purification |
Storage |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background |
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. |
Molecular Characterization |
PD-L1(Phe19-Arg238) mFc(Pro99-Lys330) 6xHis tag |
Description |
Recombinant human PD-L1 protein with C-terminal mouse Fc and 6xHis tag |
Reconstitution |
Reconstitute with deionized water |
Formulation & Reconstitution |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Usage |
Research use only |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.