Item no. |
DIM-PME100109-50ug |
Manufacturer |
DIMA Biotechnology
|
Amount |
50 ug |
Quantity options |
100 ug
10 ug
50 ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized |
Applications |
ELISA |
Specific against |
Human (Homo sapiens) |
Host |
HEK293 |
Conjugate/Tag |
HIS |
Purity |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CD126, gp80, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ |
Shipping condition |
Room temperature |
Available |
|
Manufacturer - Category |
ECD Proteins |
Manufacturer - Targets |
IL6R |
Manufacturer - Conjugate / Tag |
C-6xHis Tag |
Molecular Weight |
The protein has a predicted molecular mass of 39.4 kDa after removal of the signal peptide.The apparent molecular mass of IL6R-His is approximately 55-70 kDa due to glycosylation. |
Buffer |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
Purification |
affinity purification |
Storage |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background |
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. |
Molecular Characterization |
IL6R(Leu20-Pro365) 6xHis tag |
Description |
Recombinant Human IL6R Protein with C-terminal 6xHis tag |
Reconstitution |
Reconstitute with deionized water |
Formulation & Reconstitution |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Usage |
Research use only |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.