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Recombinant Mouse Granzyme B(G,H)/GZMB Protein (His Tag)

Recombinant Mouse Granzyme B(G,H)/GZMB Protein (His Tag)

Item no.	ELS-PKSM041035-50ug
Manufacturer	Elabscience
Amount	50 ug
Quantity options	10 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Format	Liquid
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293 cells
Conjugate/Tag	HIS
Purity	> 95 % as determined by reducing SDS-PAGE.
Sequence	Gly19-Ser247
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CCP1, CTLA-1, Ctla-1, Ctla1, Cytotoxic cell protease 1, Fragmentin-2, Granzyme B(G,H), Gzmb
Similar products	CCP1, Gzmb, CTLA-1, Fragmentin-2, Granzyme B(G, H), Cytotoxic cell protease 1, Ctla-1, Ctla1
Shipping condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Others
Manufacturer - Conjugate / Tag	C-His
Shipping Temperature	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight	26.5 kDa
Observed Molecular Weight	35 kDa
Background	Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Abbreviation	Granzyme B; GZMB
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Not Applicable
Formulation	Supplied as a 0.2 um filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	Not validated for activity
Protein Construction	Recombinant Mouse Granzyme B is produced by our Mammalian expression system and the target gene encoding Gly19-Ser247 is expressed with a 6His tag at the C-terminus.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 6/5/2025

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