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Biotinylated Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein, His,Avitag™&Tag Free

Biotinylated Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein, His,Avitag™&Tag Free

Item no.	IT1-H82Wb-25ug
Manufacturer	ACROBiosystems
Amount	25 ug
Quantity options	200 ug 25 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Conjugate/Tag	Biotin, HIS, Avi
Purity	90%
Citations	(1) Müller U, et al., 1995, Mol Biol Cell 6(4):433-48. (2) Schnapp LM, et al., 1995, J Biol Chem 270(39):23196-202. (3) Marek I, et al., 2014, Cell Adh Migr 8(4): 389-395.
NCBI	NP 003629.2 , NP_002202.2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Integrin alpha 8 beta 1,ITGA8&ITGB1
Shipping Condition	Room temperature
Available
Manufacturer - Category	Protein / MABSol® Biotin Labeled Proteins
Manufacturer - Conjugate / Tag	C-10xHis, C-Avi \| Native, Biotin-labeled
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	116.4 kDa (ITGA8) & 83.7 kDa (ITGB1)
Manufacturer - Format	Powder
Description	Biotinylated Human ITGA8&ITGB1 Heterodimer Protein, His, Avitag&Tag Free (IT1-H82Wb) is expressed from human 293 cells (HEK293). It contains AA Phe 39 - Leu 1012 (ITGA8) & Gln 21 - Asp 728 (ITGB1) (Accession # P53708-1 (ITGA8) & P05556-1 (ITGB1)).
Background	Human Integrin alpha 8 beta 1 Heterodimer Protein consists of ITGA8 and ITGB1. The integrin alpha 8 subunit, isolated by low stringency hybridization, is a novel integrin subunit that associates with beta 1. The recently identified alpha 8 integrin subunit associates with beta 1 and is predominantly expressed in smooth muscle and other contractile cells in adult tissues, and in mesenchymal and neural cells during development. In addition, Integrin alpha 8 beta 1 is a receptor for fibronectin and can promote attachment, cell spreading, and neurite outgrowth on fibronectin.
Molecule	Integrin alpha 8 beta 1
Exp Region	Phe 39 - Leu 1012 (ITGA8) & Gln 21 - Asp 728 (ITGB1)
Characteristics	Biotinylated Human ITGA8&ITGB1 Heterodimer Protein, His, Avitag&Tag Free, produced by co-expression of ITGA8 and ITGB1, has a calculated MW of 116.4 kDa (ITGA8) and 83.7 kDa (ITGB1). Subunit ITGA8 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 140-150 kDa (ITGA8) and 100-115 kDa (ITGB1) respectively due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 150 mM NaCl, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

IT1-H82Wb-25ug-datasheet.pdf

IT1-H82Wb-25ug-safety-datasheet.pdf