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Human&Mouse Chimeric WT-1 (HLA-A*02:01) Tetramer Protein (MHC-HM425T)

Human&Mouse Chimeric WT-1 (HLA-A*02:01) Tetramer Protein (MHC-HM425T)

Item no.	MHC-HM425T-500UG
Manufacturer	KactusBio
Amount	500 ug
Quantity options	100 ug 500 ug
Category	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Peptides & Proteins Recombinant Proteins Adenocarcinoma Myelofibrosis Mesothelioma Astrocytoma
Type	Proteins Recombinant
Format	Liquid
Specific against	other
Host	HEK293
Conjugate/Tag	HIS, Avi
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Formula	Supplied as 0.22μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
Sequence	Gly25-Thr206(Human HLA-A02:01 α1&α2) & Asp140-Lys241(Mouse HLA-A02:01 α3), Ile21-Met119(B2M)and RMFPNAPYL peptide
NCBI	RMFPNAPYL
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MHC, WT1, RMF, AWT1, GUD, NPHS4GUD, WAGR, WIT-2, WT33
Available
Manufacturer - Conjugate / Tag	C-His-Avi
Shipping Temperature	Shipped with blue ice
Storage Conditions	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid repeated freeze-thaw cycles.
Molecular Weight	The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.
Description	Recombinant Human&Mouse Chimeric WT-1(HLA-A02:01) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminal, tetramer is assembled by biotinylated monomer and streptavidin.It contains Gly25-Thr206(Human HLA-A02:01 α1&α2) & Asp140-Lys241(Mouse HLA-A*02:01 α3), Ile21-Met119 (B2M) and RMFPNAPYL peptide.
Background	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
Biotinylated	no
Activity	Immobilized Human&Mouse Chimeric WT-1 (HLA-A02:01) Tetramer, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-WT-1 (HLA-A02:01) Antibody, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA. See testing image for detail.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 12/25/2025

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