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Recombinant human GRP94/HSP90B1 protein

Recombinant human GRP94/HSP90B1 protein

Item no.	NKM-ATGP0276-500ug
Manufacturer	NKMAX
Amount	500 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology Neuroscience Aging & Neurological Disorders By Cell Type Carcinoma Sarcoma Peptides & Proteins Recombinant Proteins SDS-PAGE
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 90% by SDS-PAGE
Sequence	<MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSM>DDE VDVDGTVEED LGKSREGSRT DDEVVQREEE AIQLDGLNAS QIRELREKSE KFAFQAEVNR MMKLIINSLY KNKEIFLREL ISNASDALDK IRLISLTDEN ALSGNEELTV KIKCDKEKNL LHVTDTGVGM TREELVKNLG TIAKSGTSEF LNKMTEAQED GQSTSELIGQ FGVGFYSAFL VADKVIVTSK
Citations	Randow F., et al. (2001). Nat Cell Biol. 3(10):E231. Li Z., et al. (2002). Front Biosci. 7:d731-51. Yoshimura C, et al. Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors. (J Med Chem. 2021){https://pubmed.ncbi.nlm.nih.gov/33621080/}
NCBI	NP_003290.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Tumor rejection antigen GP96,Tumor rejection antigen 1,TRA1,Stress inducible tumor rejection antigen GP96,HSP90B1,Heat shock protein 90 kDa beta member 1,GRP94,GRP 9,GP96 homolog,GP96,Glucose regulated protein 94kDa,Endothelial cell (HBMEC) glycoprotein,Endoplasmin,ECGP,94 kDa glucose-regulated protein
Similar products	GRP94, HSP90B1, TRA1, Endoplasmin, 94 kDa glucose-regulated protein, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, ECGP, GP96, 94 kDa glucose regulated protein, Glucose regulated protein 94kDa, Stress inducible tumor rejection antigen GP96, Endothelial cell (HBMEC) glycoprotein, Tumor rejection antigen GP96, GRP 9, GRP9, GP96 homolog, 94kDa glucose regulated protein, 94kDa glucose-regulated protein, ATGP0276-10ug, ATGP0276-20ug, ATGP0276-50ug, ATGP0276-100ug, ATGP0276-250ug, ATGP0276-500ug, ATGP0276-1mg, ATGP0276-010, ATGP0276-020, ATGP0276-050, ATGP0276-100, ATGP0276-250, ATGP0276-500, ATGP0276-01M
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	94.4 kDa (819aa)
Description	GRP94, also known as Heat shock protein 90kDa beta, member 1 (HSP90B1), is an abundant resident endoplasmic reticulum (ER) lumenal stress protein which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. It plays an important role in maintaining protein homeostasis in the secretory pathway. Also, GRP94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells. Recombinant human GRP94 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 1mM EDTA, 0.1M NaCl, 10% glycerol,
Antigen Species	Human
Gene Category	Heat Shock Proteins
Domain	22-803aa
Species of Protein	Human
Manufacturer - Search Terms	Tumor rejection antigen GP96, Tumor rejection antigen 1, TRA1, Stress inducible tumor rejection antigen GP96, HSP90B1, Heat shock protein 90 kDa beta member 1, GRP94, GRP 9, GRP9, GP96 homolog, GP96, Glucose regulated protein 94kDa, Endothelial cell (HBMEC) glycoprotein, Endoplasmin, ECGP, 94 kDa glucose-regulated protein, 94 kDa glucose regulated protein, 94kDa glucose regulated protein, 94kDa glucose-regulated protein, ATGP0276-10ug, ATGP0276-20ug, ATGP0276-50ug, ATGP0276-100ug, ATGP0276-250ug, ATGP0276-500ug, ATGP0276-1mg, ATGP0276-010, ATGP0276-020, ATGP0276-050, ATGP0276-100, ATGP0276-250, ATGP0276-500, ATGP0276-01M
Manufacturer - Alternative Names	Tumor rejection antigen GP96, Tumor rejection antigen 1, TRA1, Stress inducible tumor rejection antigen GP96, HSP90B1, Heat shock protein 90 kDa beta member 1, GRP94, GRP 9, GP96 homolog, GP96, Glucose regulated protein 94kDa, Endothelial cell (HBMEC) glycoprotein, Endoplasmin, ECGP, 94 kDa glucose-regulated protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 7/31/2025

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