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Recombinant human PKM protein

Recombinant human PKM protein

Item no.	NKM-ATGP0429-20ug
Manufacturer	NKMAX
Amount	20 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology Metabolism Glucose Homeostasis Assisted reproductive technologies Embryo manipulation Peptides & Proteins Recombinant Proteins SDS-PAGE By Organ Thyroid Cancer
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 95% by SDS-PAGE
Sequence	<MGSSHHHHHH SSGLVPRGSH> MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVET LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS DPILYRPVAV ALDTKGPEIR TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL ISLQVKQKGA DFLVTEVENG GSLGSKKGVN
Citations	Zwerschke W., et al. (2009). Exp Cell Res. 315(16):2765-74 Mazurek S., et al. (2007). Ernst Schering Found Symp Proc. (4):99-124.
NCBI	NP_002645.3
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Pyruvate kinase muscle isoform M2,Pyruvate kinase M1/2,Pyruvate kinase muscle,Cytosolic thyroid hormone-binding protein,CTHBP,Pyruvate kinase 2/3,Threonine-protein kinase PKM2,Thyroid hormone-binding protein 1,THBP1,Opa-interacting protein 3,OIP3,Tumor M2-PK,Tyrosine-protein kinase PKM2,PK2,PK3,PKM2,p58
Similar products	PKM2, PKM, PK2, PK3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase 2/3, Tumor M2-PK, p58, M2-PK, pyruvate kinase, CTHBP, TCB, THBP1, Tumor Type M2 Pyruvate Kinase, Cytosolic thyroid hormone binding protein, OPA interacting protein 3, Pyruvate kinase muscle, Thyroid hormone binding protein cytosolic, pyruvate kinase muscle isoform M2, muscle isoform M2 OIP3, Tumour Type M2 Pyruvate Kinase, ATGP0429-10ug, ATGP0429-20ug, ATGP0429-50ug, ATGP0429-100ug, ATGP0429-500ug, ATGP0429-1mg, ATGP0429-250ug, ATGP0429-10, ATGP0429-20, ATGP0429-50, ATGP0429-100, ATGP0429-250, ATGP0429-500, ATGP0429-1
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Enzyme Activity
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	60.1 kDa (551aa)
Description	PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. This protein catalyzes the production of pyruvate and ATP from phosphoenolpyruvate. PKM2 interacting with Opa proteins, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, is required for bacterial pathogenesis. It is specifically expressed at high levels in tumor cells, and can be measured in plasma of patients with advanced breast cancer. Recombinant human PKM2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Antigen Species	Human
Gene Category	Cancer
Domain	1-531aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only	Specific activity: > 25, 000pmol/min/ug. One unit will convert 1.0pmole of phospho(enol)pyruvate to pyruvate per minute at pH 7.5 at 37C.
Species of Protein	Human
Manufacturer - Search Terms	PKM2, pyruvate kinase muscle isoform M2, CTHBP, THBP1, p58, M2-PK, Tumor M2-PK, PK2, PK3, PKM, pyruvate kinase, muscle isoform M2 OIP3, PKM, TCB, OPA interacting protein 3, PKM2, Cytosolic thyroid hormone binding protein, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Thyroid hormone binding protein cytosolic, Tumour Type M2 Pyruvate Kinase, Tumor Type M2 Pyruvate Kinase, ATGP0429-10ug, ATGP0429-20ug, ATGP0429-50ug, ATGP0429-100ug, ATGP0429-500ug, ATGP0429-1mg, ATGP0429-10ug, ATGP0429-20ug, ATGP0429-50ug, ATGP0429-100ug, ATGP0429-250ug, ATGP0429-500ug, ATGP0429-1mg, ATGP0429-10, ATGP0429-20, ATGP0429-50, ATGP0429-100, ATGP0429-250, ATGP0429-500, ATGP0429-1
Manufacturer - Alternative Names	Pyruvate kinase muscle isoform M2, Pyruvate kinase M1/2, Pyruvate kinase muscle, Cytosolic thyroid hormone-binding protein, CTHBP, Pyruvate kinase 2/3, Threonine-protein kinase PKM2, Thyroid hormone-binding protein 1, THBP1, Opa-interacting protein 3, OIP3, Tumor M2-PK, Tyrosine-protein kinase PKM2, PK2, PK3, PKM2, p58

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20 ug

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Delivery expected until 7/31/2025

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