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Recombinant human SOCS-3 protein

Recombinant human SOCS-3 protein

Item no.	NKM-ATGP2589-50ug
Manufacturer	NKMAX
Amount	50 ug
Quantity options	10 ug 250 ug 50 ug
Category	Metabolism Diabetes Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 90% by SDS-PAGE
Sequence	MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMVT HSKFPAAGMS RPLDTSLRLK TFSSKSEYQL VVNAVRKLQE SGFYWSAVTG GEANLLLSAE PAGTFLIRDS SDQRHFFTLS VKTQSGTKNL RIQCEGGSFS LQSDPRSTQP VPRFDCVLKL VHHYMPPPGA PSFPSPPTEP SSEVPEQPSA QPLPGSPPRR AYYIYSGGEK IPLVLSRPLS SNVATLQHLC RK
Citations	McKay BR, Ogborn DI, et al. (2013). Am J Physiol Cell Physiol. 304(8):C717-28. Molavi O, Wang P, et al. (2013). Br J Haematol. 161(3):348-56.
NCBI	NP_003946
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Suppressor of cytokine signaling 3,CIS3,SSI3,ATOD4,Cish3,SSI-3,SOCS-3,MGC71791
Similar products	SOCS-3, SOCS3, CIS3, SSI3, Suppressor of cytokine signaling 3, ATOD4, Cish3, MGC71791, SSI-3, ATGP2589-10ug, ATGP2589-20ug, ATGP2589-50ug, ATGP2589-100ug, ATGP2589-250ug, ATGP2589-500ug, ATGP2589-1mg, ATGP2589-10, ATGP2589-20, ATGP2589-50, ATGP2589-100, ATGP2589-250, ATGP2589-500, ATGP2589-1
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Denatured
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	29 kDa (262aa)
Description	SOCS3 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS3 is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. This protein can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. Recombinant human SOCS3 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Concentration	0.5mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Antigen Species	Human
Gene Category	Metabolism
Domain	1-225aa
Species of Protein	Human
Manufacturer - Search Terms	SOCS3, Suppressor of cytokine signaling 3, CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3, MGC71791, ATGP2589-10ug, ATGP2589-20ug, ATGP2589-50ug, ATGP2589-100ug, ATGP2589-250ug, ATGP2589-500ug, ATGP2589-1mg, ATGP2589-10, ATGP2589-20, ATGP2589-50, ATGP2589-100, ATGP2589-250, ATGP2589-500, ATGP2589-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 7/31/2025

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